PIM1 Rabbit pAb
application (WB, ELISA) & cross reactivity (Rat)
$86.94 Commercial Only
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Product details
application (WB, ELISA) & cross reactivity (Rat)
| Brand | ABclonal Technology |
|---|---|
| Manufacturer | ABclonal Technology |
| Product Size | 20ul |
| Size / Quantity | 1-EA |
Description
Size quantity: 1-EA Description: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs: 16186805, 1825810).
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